1、Codexis向Tate&Lyle出售新的食品用酶
2016年12月6日：Codexis宣布與Tate&Lyle簽訂了一份關(guān)于提供食品原料生產(chǎn)專用酶的獨(dú)家協(xié)議。
2、Amyris向Nikkol集團(tuán)出售50%的股份
2016年12月13日，Amyris公司宣布與Nikkol集團(tuán)成立化妝品合資公司。Amyris以2000萬(wàn)美元的
價(jià)格向Nikkol集團(tuán)出售其子公司Neassance50%的股權(quán)，成立該合資公司。
3、Evolva獲得生產(chǎn)甜菊糖的關(guān)鍵專利
2016年12月19日，瑞士一家生物化學(xué)公司Evolva宣布獲得美國(guó)專利申請(qǐng)的準(zhǔn)許通知書，并稱該
技術(shù)為“最經(jīng)濟(jì)有效的制造甜菊糖苷的生產(chǎn)方法”。
會(huì)議預(yù)告
1）2017年3月6日-8日，有機(jī)過(guò)程的研究和開發(fā)，帕薩迪納，美國(guó)；
https://scientificupdate.co.uk/index.php/conferences/conferences-and-
workshops/details/297-Organic-Process-Research-and-Development-Europe.html
2）2017年5月16日-18日Informex貿(mào)易展覽和會(huì)議，賓夕法尼亞州費(fèi)城，美國(guó)；
3）2017年7月9日-13日，Biotrans 2017，匈牙利布達(dá)佩斯；
最新發(fā)表文獻(xiàn)摘選：
Enzymes beat chemists in the formation of unnatural bonds.
Ducharme J, Auclair K. Chembiochem. 2016 Dec 27. doi: 10.1002/cbic.201600692. [Epub
ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28026102
Inversion of substrate stereoselectivity of horse liver alcohol
dehydrogenase by substitutions of Ser-48 and Phe-93.
Kim K, Plapp BV. Chem Biol Interact. 2016 Dec 23. pii: S0009-2797(16)30754-2. doi:
10.1016/j.cbi.2016.12.016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28025168
Alkaline serine proteases from Helicoverpa armigera: potential
candidates for industrial applications.
Akbar SM, Sharma HC. Arch Insect Biochem Physiol. 2016 Dec 26. doi:
10.1002/arch.21367. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28019702
Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-
phenyl-1, 2-ethanediol by two substrate tolerance carbonyl reductases
with cofactor regeneration.
Cui ZM, Zhang JD, Fan XJ, Zheng GW, Chang HH, Wei WL. J Biotechnol. 2016 Dec 20. pii:
S0168-1656(16)31663-7. doi: 10.1016/j.jbiotec.2016.12.016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28011130
The catalytic domain of Penicillium crustosum endoglucanase EGL1 has
cellulose-binding capacity and cellulolytic activity.
Xiong W, Yang JK, Chen FY, Han ZG. Enzyme Microb Technol. 2017 Feb;97:71-81. doi:
10.1016/j.enzmictec.2016.11.007.
https://www.ncbi.nlm.nih.gov/pubmed/28010775
Highly regioselective hydroxylation of polydatin, a resveratrol
glucoside, for one-step synthesis of astringin, a piceatannol glucoside,
by P450 BM3.
Le TK, Jang HH, Nguyen HT, Doan TT, Lee GY, Park KD, Ahn T, Joung YH, Kang HS, Yun
CH. Enzyme Microb Technol. 2017 Feb;97:34-42. doi: 10.1016/j.enzmictec.2016.11.003.
https://www.ncbi.nlm.nih.gov/pubmed/28010771
Evolutionary drivers of thermoadaptation in enzyme catalysis.
Nguyen V, Wilson C, Hoemberger M, Stiller JB, Agafonov RV, Kutter S, English J,
Theobald DL, Kern D. Science. 2016 Dec 22. pii: aah3717. doi:
10.1126/science.aah3717. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28008087
Designing selectivity in dirhodium metallopeptide catalysts for protein
modification.
Martin SC, Vohidov F, Wang H, Knudsen S, Marzec AA, Ball ZT. Bioconjug Chem. 2016 Dec
30. doi: 10.1021/acs.bioconjchem.6b00716. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28035818
Structure-guided reprogramming of a hydroxylase to halogenate its small
molecule substrate.
Mitchell AJ, Dunham NP, Bergman JA, Wang B, Zhu Q, Chang WC, Liu X, Boal AK.
Biochemistry. 2016 Dec 28. doi: 10.1021/acs.biochem.6b01173. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28029241
Directed evolution of P450cin for mediated electron transfer.
Belsare KD, Horn T, Ruff AJ, Martinez R, Magnusson A, Holtmann D, Schrader J,
Schwaneberg U. Protein Eng Des Sel. 2016 Dec 22. doi: 10.1093/protein/gzw072. [Epub
ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28007937
Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols using an
Air and Moisture stable Iron Racemization Catalyst.
B?ckvall JE, Gustafson KG, Guemundsson A, Lewis K. Chemistry. 2016 Dec 22. doi:
10.1002/chem.201605754. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28005307
Intracellular Microreactors as Artificial Organelles to Conduct Multiple
Enzymatic Reactions Simultaneously.
Godoy-Gallardo M, Labay C, Jansman MM, Ek PK, Hosta-Rigau L. Adv Healthc Mater. 2016
Dec 22. doi: 10.1002/adhm.201601190. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28004530
Gene cloning, recombinant expression, purification and characterization
of L-methionine decarboxylase from Streptomyces sp. 590.
Hayashi M, Okada A, Yamamoto K, Okugochi T, Kusaka C, Kudou D, Nemoto M, Inagaki J,
Hirose Y, Okajima T, Tamura T, Soda K, Inagaki K. J Biochem. 2016 Dec 21. pii:
mvw083. doi: 10.1093/jb/mvw083. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/28003434
A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate
Decarboxylase into A Kinase.
Motoyama K, Unno H, Hattori A, Takaoka T, Ishikita H, Kawaide H, Yoshimura T, Hemmi
H. J Biol Chem. 2016 Dec 21. pii: jbc.M116.752535. doi: 10.1074/jbc.M116.752535.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28003359
Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene
Replaces the Prolyl Peptide Bond.
Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT. Biochemistry. 2016 Dec 21.
doi: 10.1021/acs.biochem.6b00976. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28001367
Semi-Rational Engineering of Leucine Dehydrogenase for L-2-Aminobutyric
Acid Production.
Xu JM, Cheng F, Fu FT, Hu HF, Zheng YG. Appl Biochem Biotechnol. 2016 Dec 20. doi:
10.1007/s12010-016-2369-0. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28000046
Production of 8,11-Dihydroxy and 8-Hydroxy Unsaturated Fatty Acids from
Unsaturated Fatty Acids by Recombinant Escherichia coli Expressing 8,11-
Linoleate Diol Synthase from Penicillium chrysogenum.
Kim MJ, Seo MJ, Shin KC, Oh DK. Biotechnol Prog. 2016 Dec 20. doi: 10.1002/btpr.2426.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27997074
Peroxygenases en route to becoming dream catalysts. What are the
opportunities and challenges?
Wang Y, Lan D, Durrani R, Hollmann F. Curr Opin Chem Biol. 2016 Dec 16;37:1-9. doi:
10.1016/j.cbpa.2016.10.007. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/27992798
Enantiocomplementary Synthesis of ?-Nitroketones Using Designed and
Evolved Carboligases.
Garrabou X, Verez R, Hilvert D. J Am Chem Soc. 2016 Dec 22. doi:
10.1021/jacs.6b11928. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27992715
Broad substrate affinity and catalytic diversity of fibrinolytic enzyme
from Pheretima posthumous-Purification and molecular characterization
study.
Verma MK, Pulicherla KK. Int J Biol Macromol. 2017 Feb;95:1011-1021. doi:
10.1016/j.ijbiomac.2016.10.090.
https://www.ncbi.nlm.nih.gov/pubmed/27984142
Laccase Activity in CTAB-Based Water-in-Oil Microemulsions.
Azimi M, Nafissi-Varcheh N, Faramarzi MA, Aboofazeli R. Iran J Pharm Res. 2016
Summer;15(3):441-452.
https://www.ncbi.nlm.nih.gov/pubmed/27980579
Green synthesis of β-sitostanol esters catalyzed by the versatile
lipase/sterol esterase from Ophiostoma piceae.
Molina-Gutiérrez M, Hakalin NL, Rodríguez-Sanchez L, Prieto A, Martínez MJ. Food
Chem. 2017 Apr 15;221:1458-1465. doi: 10.1016/j.foodchem.2016.11.005.
https://www.ncbi.nlm.nih.gov/pubmed/27979115
Chemical biology: A radical change in enzyme catalysis.
Bornscheuer UT. Nature. 2016 Dec 14;540(7633):345-346. doi: 10.1038/540345a. No
abstract available.
https://www.ncbi.nlm.nih.gov/pubmed/27974776
Accessing non-natural reactivity by irradiating nicotinamide-dependent
enzymes with light.
Emmanuel MA, Greenberg NR, Oblinsky DG, Hyster TK. Nature. 2016 Dec 14;540(7633):414-
417. doi: 10.1038/nature20569.
https://www.ncbi.nlm.nih.gov/pubmed/27974767
Functional Characterization of a Novel Amidase Involved in
Biotransformation of Triclocarban and its Dehalogenated Congeners in
Ochrobactrum sp. TCC-2.
Yun H, Liang B, Qiu J, Zhang L, Zhao Y, Jiang J, Wang A. Environ Sci Technol. 2017
Jan 3;51(1):291-300. doi: 10.1021/acs.est.6b04885.
https://www.ncbi.nlm.nih.gov/pubmed/27966913
Eichhornia crassipes: Agro-waster for a novel thermostable laccase
production by Pycnoporus sanguineus SYBC-L1.
Wang Z, Liu J, Ning Y, Liao X, Jia Y. J Biosci Bioeng. 2016 Dec 7. pii: S1389-1723(16)
30287-0. doi: 10.1016/j.jbiosc.2016.09.005. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27964864
Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin
Biosynthesis.
Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC. J Am Chem Soc. 2016 Dec 14;138
(49):16024-16036. https://www.ncbi.nlm.nih.gov/pubmed/27960309
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